Acetyl-L-carnitine

Acetyl-L-carnitine is a chemical compound naturally produced in the kidneys and liver. Acetyl-L-carnitine helps to reduce oxidative stress. It's believed to be involved in nerve cell function and regeneration.

In a few clinical trials, people who had diabetic neuropathy had reduced pain, improvements in other sensory problems and improvements in nerve function tests. Some of these studies also suggested that the treatment effect is greater when started early in the disease's course. More studies are needed.

Acetyl-L-carnitine supplements are generally considered safe when taken as directed. Side effects may include nausea, vomiting or agitation.

Don't use acetyl-L-carnitine if you use warfarin (Coumadin, Jantoven), a blood-thinning medication, because the combination increases warfarin's effect and potentially the bleeding risk. For people who have hypothyroidism or a history of seizures, acetyl-L-carnitine may make these conditions worse.